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hearing 2

CRISPR/Cas9 1

LKB1 1

TPRN 1

actin filament 1

kinocilium 1

mice 1

planar cell polarity 1

stereocilia 1

stereociliary bundles 1

stereociliary rootlet 1

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is essential for the integrity of stereociliary rootlet in cochlear hair cells in mice

Yuqin Men, Xiujuan Li, Hailong Tu, Aizhen Zhang, Xiaolong Fu, Zhishuo Wang, Yecheng Jin, Congzhe Hou, Tingting Zhang, Sen Zhang, Yichen Zhou, Boqin Li, Jianfeng Li, Xiaoyang Sun, Haibo Wang, Jiangang Gao

Frontiers of Medicine 2019, Volume 13, Issue 6, Pages 690-704 doi: 10.1007/s11684-018-0638-8

Abstract: Transmission electron microscopy images of stereociliary bundles in the mutant mice showed some stereociliaryThe central cores of the stereociliary rootlets possessed hollow structures with surrounding loose peripheralWe propose that is critical to the retention of the integrity of the stereociliary rootlet.Loss of in -null mice caused the disruption of the stereociliary rootlet, which resulted in damageto stereociliary bundles and hearing impairments.

Keywords： TPRN stereocilia stereociliary rootlet actin filament CRISPR/Cas9 hearing

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Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice

Yuqin Men,Aizhen Zhang,Liwen Zhang,Yecheng Jin,Zhishuo Wang,Jing Zhao,Xiaolin Yu,Jian Zhang,Jiangang Gao

Frontiers of Medicine 2016, Volume 10, Issue 4, Pages 481-489 doi: 10.1007/s11684-016-0494-3

Abstract: Immunofluorescence and scanning electron microscopy revealed that stereociliary bundles in LKB1^{Pax2The orientation of stereociliary bundles and the migration of kinocilia are critical indicators of planar}

Keywords： LKB1 stereociliary bundles kinocilium planar cell polarity hearing mice